Oxygen Therapy in Patients With Acute Heart Failure: Friend or Foe?

نویسندگان

  • Nariman Sepehrvand
  • Justin A Ezekowitz
چکیده

Supplemental oxygen, a therapy that has been used for more than a century, is recommended in all practice guidelines in the management of hypoxemic (peripheral oxygen saturation <90% to 94% or partial arterial oxygen pressure <60 mm Hg) patients with acute heart failure, but its use in normoxemic patients is controversial. Several pre-clinical and early clinical studies have shown the detrimental effects of oxygen therapy and subsequent hyperoxia in patients with normal oxygen saturation levels. These effects are suggested to be gauged by the increased production of reactive oxygen species and the related oxidative stress and by the reductions in coronary blood flow and myocardial oxygen consumption resulting from hyperoxia-induced vasoconstriction in the cerebral, coronary, and systemic vasculature. Considering these findings, recent practice guidelines are diverging from the previous consensus that oxygen should be administered routinely in patients with cardiac disease, but this new direction is also based on expert opinions rather than evidence such as well-designed trials. In this review, the authors summarize current evidence regarding the cardiovascular effects of supplemental oxygen therapy, particularly evidence from the field of acute heart failure, and delineate knowledge gaps in the field and future directions in research.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Epinephrine for acute decompensated heart failure and low output state: friend or foe?

Friend or foe? Nuccia Morici , Alice Sacco , Fabrizio Oliva , Stefano Ferrari , Roberto Paino , Filippo Milazzo , Maria Frigerio , Roberto Pirola , Silvio Klugmann , Antonio Mafrici a,⁎ a Intensive Cardiac Care Unit, Cardiovascular Department at Niguarda Ca'Granda Hospital, Milan, Italy b Interventional Cardiology, Section 1, Cardiovascular Department at Niguarda Ca'Granda Hospital, Milan, Ital...

متن کامل

Heparin and bone marrow-derived cell therapy: friend or foe?

Cell therapy has been shown to be useful in treating some patients with acute myocardial infarction, congestive heart failure, and ischemic limbs.1–7 In harvesting, storing, or injecting the bone marrow–derived mononuclear cells (BMCs), an anticoagulant, such as heparin, is often added to prevent cell clumping. In this issue of Circulation Research, Drs Stephanie Dimmeler, Andreas Zeiher, and t...

متن کامل

Comparison of the effect of broncodiatory albotrol from spacer and nebulazor foe freatment of Astma patients

Tavana S1, Nadi E1, Ansari M2, zeraati F3, Hashemi H1, Mani Kashani Kh4, Mavallat M5 1. Assistant professor, Department of internal, Faculty of medicine, Hamedan University of medical sciences 2. Associate professor, Department of internal, Faculty of medicine, Hamedan University of medical sciences 3. Associate professor, Department of Pharmacology, Faculty of medicine, Hamedan Univers...

متن کامل

Apocrine Metaplasia in Intraductal Papilloma with Foci of DCIS: A Friend or Foe?

Malignant papillary neoplasms of the breast comprise a number of microscopically distinct lesions, where apocrine metaplasia is commonly found in papillomas compared to other papillary lesions including papillary carcinomas. However, association of apocrine metaplasia in papilloma with Ductal Carcinoma in Situ (DCIS) is not very well defined. The lesions with apocrine metaplasia are not only di...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • JACC. Heart failure

دوره 4 10  شماره 

صفحات  -

تاریخ انتشار 2016